Even though Peyton and Eli Manning don't play professional football anymore, they still keep the competitive spirit alive. In most cases, it's light-hearted. For instance, in a brand-new commercial for Tylenol, Peyton dares his younger brother Eli to a foot race.

"My brother Eli made the embarrassing mistake of claiming to be the faster Manning," said Peyton in the latest commercial posted on his Instagram account on April 22. "So I challenged him to race in a 40-yard dash."

Peyton knows he isn’t the fastest runner. During the ad, Peyton perfectly describes his style.

"Am I a speed demon?" said Peyton. "No, I am not. But, I make up for that with preparation. Meticulous preparation."

Filming the ad for the pain-relieving product brand, Peyton said that he will be preparing by using Tylenol to help with his sore muscles.

This is part of a series of ads for 2025 and 2026 where Peyton promotes Tylenol Rapid Release Gels and Tylenol PM.

Peyton once partnered with Tylenol for a humorous commercial centered around the different kinds of “Eli headaches” caused by his brother Eli.

This might remind fans of the Kick of Destiny challenge from 2025. The showdown between Eli Manning and Peyton Manning started with Eli winning the toss and sending Peyton out first.

Both missed from 25 yards in Round 1, but the younger Manning recovered in Round 2 after Peyton’s 20-yard try bounced off the upright. Eli then stepped up, rallied the crowd, and nailed the game-winning kick.

Peyton and Eli Manning have always been in a healthy competition. Looking back at their careers, both brothers are legends. Peyton was a statistical powerhouse, throwing for over 71,000 yards and winning a record five NFL MVP awards. He won Super Bowls with both the Indianapolis Colts and the Denver Broncos.

Eli, on the other hand, played his entire career with the New York Giants, leading them to two Super Bowl wins and earning the MVP trophy in both of those championship games.

Later, the brothers launched the ManningCast in 2021, an alternate football broadcast that became a huge hit because of their comedic exchanges and great guests.

Eli Manning’s Gift for Peyton Manning

Peyton cemented his legacy with two Super Bowl wins and a Pro Football Hall of Fame in 2021. But in 1998, there were still plenty of doubts surrounding his future.

The Indianapolis Colts made Peyton the No. 1 pick in the 1998 NFL Draft. But his rookie season came with growing pains as he tossed 28 interceptions, a record that remains unmatched. This gave his brother Eli an idea.

In one of the episodes of the Manning Cast, this January this year, Eli gifted his brother Peyton a framed collage. It featured the football card of every player who intercepted Peyton in his rookie season.

“I’m sure you’ll put that in your bedroom, I assume,” Eli further joked. “Somewhere nice where you can look at it every day.”

It's time to see whether Eli will accept Peyton's 40-yard challenge.

Share your thoughts on the Eli-Peyton bond.

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Written by

Aaindri Thakuri

Edited by

Soheli Tarafdar